FIGURE

Fig. 4

ID

ZDB-FIG-210504-4

Publication

Kenyon et al., 2021 - Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

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Fig. 4

Compounds UoS-7692 and UoS-9645 do not block I_K,neo. (A and B) Basolateral currents measured from mid-basal coil OHCs in response to a series of voltage steps from a holding potential of –84 mV before, during, and after extracellular exposure to 50 μM UoS-5247 (A) and 50 μM UoS-7692 (B). Schematic representation of the voltage-step protocol is shown below each of the current traces. Cell capacitances were 6.8 pF (A) and 7.0 pF (B). (C and D) Current-voltage curves measured from cells exposed to 50 μM UoS-5247 (C) and UoS-7692 (D) before, during, and after compound superfusion. (E and F) Average steady-state current-voltage curves of the 8 protective compounds at 50 μM. Currents normalized to steady-state control current at +46 mV for each cell. Cell numbers: UoS-962 (n = 2); UoS-3606 (n = 2); UoS-3607 (n = 2); UoS-5247 (n = 5); UoS-7691 (n = 4); UoS-7692 (n = 4); UoS-8052 (n = 5); UoS-9645 (n = 5).

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Acknowledgments

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