ZFIN Image: Kenyon et al., 2021, Fig. 4

Image

Figure Caption

Fig. 4 Compounds UoS-7692 and UoS-9645 do not block I_K,neo. (A and B) Basolateral currents measured from mid-basal coil OHCs in response to a series of voltage steps from a holding potential of –84 mV before, during, and after extracellular exposure to 50 μM UoS-5247 (A) and 50 μM UoS-7692 (B). Schematic representation of the voltage-step protocol is shown below each of the current traces. Cell capacitances were 6.8 pF (A) and 7.0 pF (B). (C and D) Current-voltage curves measured from cells exposed to 50 μM UoS-5247 (C) and UoS-7692 (D) before, during, and after compound superfusion. (E and F) Average steady-state current-voltage curves of the 8 protective compounds at 50 μM. Currents normalized to steady-state control current at +46 mV for each cell. Cell numbers: UoS-962 (n = 2); UoS-3606 (n = 2); UoS-3607 (n = 2); UoS-5247 (n = 5); UoS-7691 (n = 4); UoS-7692 (n = 4); UoS-8052 (n = 5); UoS-9645 (n = 5).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ JCI Insight