FIGURE
Fig. 3
- ID
- ZDB-FIG-210504-3
- Publication
- Kenyon et al., 2021 - Identification of a novel series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity
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Fig. 3
UoS-5247 and UoS-8052 are cytotoxic at a concentration of 100 μM. (A–H) Representative images from the mid-basal ROI of Texas red phalloidin-stained cultures that were exposed to 100 μM of UoS-962 (A), UoS-3606 (B), UoS-3607 (C), UoS-5247 (D), UoS-7691 (E), UoS-7692 (F), UoS-8052 (G), and UoS-9645 (H) alone for 48 hours. UoS-5247 (D) and UoS-8052 (G) show widespread cell death. Images are representative of n = 2 experiments. UoS-8052 was selectively toxic to OHCs, whereas UoS-5247 killed both inner and outer hair cells. Scale bar: 25 μm. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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