FIGURE

Figure 6

ID

ZDB-FIG-210413-8

Publication

Ivica et al., 2021 - The intracellular domain of homomeric glycine receptors modulates agonist efficacy

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Figure 6

Conformational changes in the transmembrane domains of the zebrafish full-length GlyR andGlyR ΔICD. The full-length GlyR and the GlyR ΔICD are in the open (A and C) and closed (B and D) states, respectively. A and B, superposition of transmembrane domains from a single subunit from the full-length GlyR and the GlyR ΔICD from lateral view. C and D, superimposition of the (–)subunits illustrates the relative movements in the transmembrane domain of the (+)subunit. The view is from the intracellular side. GlyR full-length structures from Yu et al. (57), glycine bound open, PDB ID code 6PM6; taurine bound closed, PDB ID code 6PM3. GlyR ΔICD structures from Du et al. (2), glycine bound open, PDB ID code 3JAE; closed, PDB ID code 3JAD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.