FIGURE

Fig. 2

ID
ZDB-FIG-210413-49
Publication
Luo et al., 2020 - Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish
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Fig. 2

Disruption of tissue-specific genes in larvae and adult zebrafish. (A) Representative images of various single-deletion mutations, and gfapWT control in 3-month-old adult fish. The fluorescent radial glia phenotype was observed based on mCherry-labelled Gfap expression, which failed to co-localize with Nf1, Rb1 or Tp53 expression in brain tissues of transgenic zebrafish (arrowheads; right), whereas partial co-localizations of mCherry-labelled Gfap with Nf1, Rb1 or Tp53 expression were observed in gfapWT fish (arrows; left). Scale bars = 50 μm. (B) Merged bright and fluorescent images showing mCherry-labelled Gfap expression in the cerebellum and medulla in 3-month-old gfapWT fish. Scale bars = 500 μm. (C) Coronal sections of the images shown in i–iii. Robust mCherry-labelled Gfap expression was observed along the midline and dorsal lining of the fourth ventricle. Scale bars = 50 μm.

Expression Data
Genes:
Fish:
Anatomical Term:
Stage: Adult

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
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