FIGURE

Figure 13

ID

ZDB-FIG-210409-195

Publication

Miklosz et al., 2021 - Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models

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Figure 13

Histopathology of the heart tissue samples from mice treated five times with vehicle (VEH, 1 mL/kg) (a), protamine sulfate alone (PS, 1.5 mg/kg, 1 mL/kg) (b), or with unfractionated heparin (UFH, 1.5 U/kg, 1 mL/kg) (c) and only UFH (1.5 U/kg, 1 mL/kg) (d). The concentrations of cardiac troponin T type 2 (TNNT2) in mice serum in the first week after a single administration and in the 5th week after four administrations of drugs (e). The results are shown as the medians (line) with the interquartile ranges (box), along with maximum and minimum values (whiskers). Note: * p < 0.05 vs. VEH within the group, Kruskal–Wallis ANOVA with Dunn’s post–hoc test, n = 6–8.

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