Figure 9
- ID
- ZDB-FIG-210409-191
- Publication
- Miklosz et al., 2021 - Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models
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The effects of protamine sulfate (PS) and its complexes with unfractionated heparin (UFH) on perfusion of paw vessels. The course of perfusion of paw vessels was tracked for 60 min after short–duration intravenous infusion (5 min; 2 mL/h) of PS at dose of 1.5 (a) or 10 mg/kg (b) following intravenous administration of vehicle (VEH, 1 mL/kg) or UFH (150 or 1000 U/kg, 1 mL/kg). Results are shown as means (lines) with SEMs. The perfusion of paw vessels at 0 min of the experiment were 0.08 (0.04–0.14) for VEH, 0.07 (0.05–0.11) for PS 1.5 mg/kg, 0.07 (0.02–0.13) for UFH 150 U/kg + PS 1.5 mg, 0.06 (0.03–0.1) for UFH 150 U/kg, 0.09 (0.05–0.13) for PS 10 mg/kg, 0.1 (0.06–0.14) for UFH 1000 U/kg + PS 10 mg/kg, 0.08 (0.05–0.13) for UFH 1000 U/kg. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. VEH, Kruskal–Wallis ANOVA with Dunn’s post–hoc test, n = 5–8. |