FIGURE

Figure 4.

ID
ZDB-FIG-210319-47
Publication
Jung et al., 2021 - Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos
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Figure 4.

Inhibition of SHH signaling with cyclopamine resulted in developmental defects in the midbrain of zebrafish embryos at 24?hpf. (A?D) Zebrafish embryos at 24?hpf which were treated 0.2% and 0.6% EtOH from 4?hpf. 0.6% EtOH-exposed embryos showed similar phenotypes of midbrain and MHB in comparison to those of 0.2% EtOH-exposed embryos. (E and F) Cyclopamine-treated embryos (20??M) showed reduction in width of the midbrain and dorsally shrunken midbrain in comparison to those of EtOH controls. (G and H) 60??M cyclopamine-treated embryos exhibited severe defects in the midbrain. (I?L) Spatiotemporal expression patterns of otx2b in the midbrain of cyclopamine-treated embryos at 24?hpf. CCP, cyclopamine. (A?L) Scale bars: 50??m.

Expression Data
Gene:
Fish:
Condition:
Anatomical Term:
Stage: Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In:
Stage: Prim-5

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Animal Cells Syst (Seoul)
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