Figure 3—figure supplement 1.

Developmental relationships between FGPs and mCP vasculature in WT, <italic>vegfab<sup>-/-</sup></italic>, and <italic>vegfc<sup>-/-</sup>;vegfd<sup xmlns:xlink='http://www.w3.org/1999/xlink'>-/-</sup></italic> larvae.

(A–C") Dorsal views of 120 hpf WT (A–A"), vegfab-/- (B–B"), and vegfc-/-;vegfd-/- (C–C") heads of larvae that carried the Tg(kdrl:EGFP) (A–C) and Tg(lyve1:DsRed) (A’–C’) transgenes (merged images shown in A"–C"). All of the vegfab-/- larvae that lacked the DLV (n = 7) formed FGPs in the dorsal surfaces of the brain meninges (B–B"), as observed in WT larvae (n = 13). In contrast, vegfc-/-;vegfd-/- larvae (C–C") that exhibited the complete loss of FGPs (n = 9) formed the DLV and PCeV, as observed in WT fish. Yellow arrows point to the DLV and white arrows to the FGPs. Scale bar: 50 µm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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