FIGURE

Fig. 4

ID

ZDB-FIG-210119-14

Publication

El-Sahli et al., 2021 - A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature

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Fig. 4

Verteporfin-NP also inhibits angiogenesis-associated genes in vitro in human TNBC cells.

A Schematic showing that HIF-1α is a master regulator in angiogenesis and other tumorigenic processes. B Luciferase reporter activity of HIF-1α activities in MDA-MB-231 cells treated with control DMSO, paclitaxel (25 nM), verteporfin (1.25 µM), CA4 (25 nM), and different combinations for 24 hrs. C RT-qPCR analysis showing the changes of VEGF gene expression in MDA-MB-231 cells after 24 hrs of treatment with E (empty-NP), 25 nM P (paclitaxel-NP), 1.25 µM V (verteporfin-NP), 25 nM C (combretastatin-NP), and different combinations. Data are expressed as mean ± SD, n = 3. *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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