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Fig. 2

ID

ZDB-FIG-210119-12

Publication

El-Sahli et al., 2021 - A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature

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Fig. 2

Verteporfin-NP more effectively inhibits the migration of TNBC cells and fully suppresses YAP target genes upregulated by paclitaxel-NP and/or combretastatin-NP.

A TNBC MDA-MB-231 cells were grown to confluence, treated with mitomycin to inhibit cell proliferation, and then scratched and quantified for migration after incubation with E (empty-NP), 5 nM P (paclitaxel-NP), 250 nM V (verteporfin-NP), 5 nM C (combretastatin-NP), or different combinations for 48 hrs. B Representative images of A. C, D RT-qPCR analysis of changes of YAP target gene in MDA-MB-231 cells after 24 -hr of treatment with E (empty-NP), 25 nM P (paclitaxel-NP), 1.25 µM V (verteporfin-NP), 25 nM C (combretastatin-NP), and different combinations. Data represent means ± SEM, *P < 0.05, **P < 0.01, ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

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