FIGURE

Figure 7

ID

ZDB-FIG-210108-49

Publication

Christensen et al., 2020 - Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson's Disease in Zebrafish

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Figure 7

Effects of 4-phenylbutyrate (PBA) on motor activity of MPP+-treated zebrafish larvae. Larvae in the absence (Control) or presence of 500 μM MPP+ were treated with vehicle (black bars) or 100 μM PBA (white bars). Motor activity was evaluated for (A) distance swum (mm); (B) frequency of movement; (C) cumulative time of movement (s) and (D) movement bout duration (s) during five consecutive light-on phases. Data are presented as means ± SEM from a single experiment, control group n = 32, MPP+ group n = 31, PBA group n = 32, MPP+/PBA group n = 32. Normality was tested using D’Agostino and Pearson omnibus normality test followed by two-way ANOVA and Tukey’s post hoc analysis. P-value for interaction between neurotoxin exposure and drug treatment is shown above the graph. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, for multiple comparisons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Behav. Neurosci.