FIGURE

Figure 5

ID

ZDB-FIG-210108-47

Publication

Christensen et al., 2020 - Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson's Disease in Zebrafish

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Figure 5

Effects of glial-derived neurotrophic factor (GDNF) on motor activity of MPP+-treated zebrafish larvae. Larvae were incubated in the absence (black bars) or presence (white and gray bars) of 500 μM MPP+ and injected with 72.9 ng GDNF (gray bars) at 4 dpf before assessing motor activity at 6 dpf for (A) distance swum (mm); (B) frequency of movement; (C) cumulative time of movement (s) and (D) swim bout duration during five consecutive light-on phases. Data are represented as means ± SEM from a single experiment, control group n = 32, MPP+ group n = 31, GDNF group n = 32. Normality was tested using D’Agostino and Pearson omnibus normality test followed by the two-tailed Kruskal–Wallis test (p-value shown above graph) and Dunn’s post hoc analysis. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, for multiple comparisons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Behav. Neurosci.