FIGURE

Figure 2

ID

ZDB-FIG-201104-6

Publication

Knüfer et al., 2020 - Cadherins regulate nuclear topography and function of developing ocular motor circuitry

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Figure 2

Ocular motor nuclei of <italic>cdh2ΔEC</italic> larvae retain key characteristics of dorsoventral organisation but appear disorganised compared to wild types.

(A, B) Dorsal views of the entire z-stack for representative wild-type Isl1:GFP and cdh2ΔEC larvae at 72 hpf. Example embryo in (B) is the same as shown in Figure 2D. (A’-A’’’’’; B’–B’’’’’) Sub-stack projections of three combined dorsoventral (DV) subdivisions (z0–z14) moving from dorsal to ventral for wild-type Isl1:GFP (A–A’’’’’) and cdh2ΔEC (B–B’’’’’) larvae. All images are maximum intensity projections of confocal z-stacks. nIII: rostral to MHB; nIV: caudal to MHB. Arrows indicate differences in clustering of dorsal neurons and less organised ventral population in the case of cdh2ΔEC larvae. MHB: midbrain-hindbrain boundary, mid: midline. Scale bars = 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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