FIGURE

Figure 4

ID

ZDB-FIG-201003-259

Publication

Bedell et al., 2020 - A vertebrate model to reveal neural substrates underlying the transitions between conscious and unconscious states

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Figure 4

Hill plots of a sedative drug. Zebrafish respond to dexmedetomidine at physiological concentrations for loss of SPONT (A, light blue circle). This response is able to be reversed using an alpha-2 adrenergic antagonist, atipamezole (A, dark blue square) at 100 µM. There is a decrease in movement seen in the ELEC (A, purple triangle). However, even at the highest doses, we were unable to achieve complete loss of movement. (B) There is no significant difference seen with this drug using the TAP (p = 0.4). All graphs were created with 3–8 replicates per point and 8–12 zebrafish larvae used per replicate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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