Fig. 4

a Structure of pedigree; the genotypes and sex of animals is indicated. White boxes, wild-type animals unrelated to the dnmt1-mutant lineage; blue boxes, genotypically wild-type animals arising from various crosses in the dnmt1-mutant lineage. The presence (+) or absence (−) of larval and adult phases of T cell development in different generations of the pedigree are indicated on the right, with colors matching the relevant genotypes. The ± sign indicates that larval T cell development is impaired in some but not all G4 and G5 animals. b Genotypically wild-type (dnmt1^+/+) males and females of the G4 generation give rise to off-spring with (G4*) or without (G4⁺) impaired larval T cell development when crossed to wild-type animals. c Normal adult hematopoiesis in fish of different genetic backgrounds. Whole kidney marrow cells were analyzed by flow cytometry (see Fig. 2c, left panel) and cell numbers in the lymphoid and myeloid gates were counted⁴⁷. The genotype of animals is indicated to the right; TLEK and Assam represent wild-type strains. Note the normal lymphoid/myeloid ratios in adult G4* animals. Each data point represents one animal. Source data are provided as Source Data file.