FIGURE

Fig. 7

ID

ZDB-FIG-200910-40

Publication

Chetty et al., 2020 - Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish

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Fig. 7

Inhibition of MAPK signaling during vasculogenesis exacerbates angiogenic defects in Etv2-deficient embryos. (A?D) Compound microscope images of 48 hpf Tg(kdrl:GFP) wild-type and etv2 MO (5 ?ng)-injected embryos treated either with DMSO or 15 ??M MAPK inhibitor SL327. Note the severe ISV sprouting defects in etv2 MO ?+ ?SL327 embryos (D) compared to etv2 MO ?+ ?DMSO embryos (C). (E,F) Quantitative analysis of ISV number and height. Note the decrease in total number of ISVs (E) and percentage of full sprouts (F) in etv2 MO ?+ ?SL327 embryos compared to etv2 MO ?+ ?DMSO embryos. ?P ?< ?0.05, ???P ?< ?0.001. Horizontal bar within violin plots represents median.

Expression Data

Gene:	EGFP
Fish:	s843Tg s843Tg + MO2-etsrp
Condition:	chemical treatment: SL-327
Knockdown Reagent:	MO2-etsrp
Anatomical Terms:	blood vasculature blood vessel intersegmental vessel
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg s843Tg + MO2-etsrp
Condition:	chemical treatment: SL-327
Knockdown Reagent:	MO2-etsrp
Observed In:	blood vasculature blood vessel intersegmental vessel
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 465(1), Chetty, S.C., Sumanas, S., Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish, 11-22, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.