FIGURE

Fig. 2.

ID

ZDB-FIG-200910-14

Publication

Spinazzola et al., 2020 - Effect of serotonin modulation on dystrophin-deficient zebrafish

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Fig. 2.

Short-term assay of serotonin, serotonin precursors, products and receptor agonists. (A–E) Treatment with serotonin, 5-hydroxy-L-tryptophan (5-HTP), tryptophan, melatonin and cisapride did not significantly decrease the percentage of zebrafish exhibiting the affected muscle phenotype detected by birefringence. Treatment with 2.5 μg/ml aminophylline significantly decreased the percentage of affected fish. Data represent means±s.e.m.; *P<0.05 versus paired control by one-way ANOVA and Bonferroni post-hoc test. Values above each column indicate the number of sapje (N) and sapje-like (n) fish treated with the respective drug. (F) Both affected and unaffected zebrafish treated with ≤16.5 μM cisapride exhibited abnormal body morphology.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dmd^cl100/cl100 dmd^{ta222a/ta222a}
Condition:	chemical treatment by environment: aminophylline
Observed In:	skeletal muscle
Stage:	Day 4

Phenotype Detail

Acknowledgments

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