FIGURE

Fig. 7

ID

ZDB-FIG-200829-7

Publication

Satapathy et al., 2020 - Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition

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Fig. 7

LTC<sub>4</sub>-induced 15-PGDH promotes differentiation in transgenic zebrafish xenografts.

a Schematic diagram showing the experimental setup of HT-29 cell-based xenografts in transgenic zebrafish (n = 20 in each group). b Immunofluorescence analysis of whole-mount staining of xenografted transgenic zebrafish Tg(fli1:EGFP) embryos with anti-Mucin-2 antibodies after the injection of shCTRL- or shGLI1-transfected HT-29 cells with or without LTC₄ stimulation into the perivitelline space (PVS)⁵³. c Graphical representation of the mean fluorescent intensity of Mucin-2-expressing HT-29 colon cancer cells transfected with shCTRL or shGLI1 with or without LTC₄ stimulation. The scale bars are as indicated in the images. d Schematic mechanistic model described in the study. Mean ± SEM, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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