FIGURE

Fig. 11

ID

ZDB-FIG-200728-52

Publication

Brandt et al., 2020 - Core Hippo pathway components act as a brake on Yap/Taz in the development and maintenance of the biliary network

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Fig. 11

sav1 and stk3 display a synergistic genetic interaction. (A-D?) Toluidine Blue stained Epon sections of liver and gallbladder in wild-type, sav1?/?, stk3?/? and sav1?/?;stk3?/? larvae at 7 and 10?dpf. Gb, gallbladder. Red dashed lines outline the liver. Scale bars: 100 ?m. (E) Ratiometric analysis at 8?dpf of BODIPY FL C5 gallbladder uptake in larvae from a sav1+/?;stk3+/? incross. (F) TEM of wild-type, sav1?/? and sav1?/?;stk3?/? Epon sections at 10?dpf reveals the most severe phenotype in sav1?/?;stk3?/? larvae. (G) Toluidine Blue stained epon sections of proximal renal tubules in wild-type, sav1?/?, stk3?/? and sav1?/?;stk3?/? larvae at 10?dpf. PRT, proximal renal tubule. Only double mutants display a dysplastic and fibrotic phenotype. (H) TEM of larvae from G.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sav1^mw95/mw95 stk3^mw96/mw96; sav1^mw95/mw95
Observed In:	gall bladder pronephric duct proximal region
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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