FIGURE

Fig. 6

ID

ZDB-FIG-200716-47

Publication

Zeng et al., 2019 - Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

ZIP4 silencing enhances the antitumor effect of radiation in vivo and Schematic summary of this study.

a, b Sh-ZIP4 and LVRH C666-1 cells (1 × 10⁷) were subcutaneously inoculated into the right hind limb of nude mice (N = 7 per group). When the size of the tumors reached about 50 mm³, tumors were irradiated at 5 Gy per day for 4 days (on day 1, 3, 6, and 8). Tumor size was measured and weight was recorded. c TUNEL staining of C666-1 xenografts (Scale bar = 50 μm) (P < 0.01). d PCNA IHC staining of C666-1 xenografts (P < 0.01). e Overexpression of ZIP4 induces the EMT process through the PI3K/Akt pathway and further promotes migration and invasion of NPC cells. Meanwhile, ZIP4 enhanced radiation-induced apoptosis and growth inhibition of human C666-1 cells. These findings support our clinical observations, indicating that ZIP4 elevation is associated with clinical T classification, N classification, and clinical stage, and leads to adverse survival outcomes of NPC

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.