FIGURE

3

ID

ZDB-FIG-200709-34

Publication

García-Poyatos et al., 2020 - Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish

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Diet‐induced recovery of <italic>scaf1</italic><sup>−/−</sup> phenotypes in males and diet effect in <styled-content toggle='no' style='fixed-case'>SCAF</styled-content>1‐deficient mice

Representative images of scaf1^−/− and scaf1^+/+ males fed with the indicated diets.

B, C

Size of males after the indicated diet. (B) Changes in length and (C) weight over time (Δ1 +/+ n = 10, Δ1 −/− n = 10, Δ2 +/+ n = 10, Δ2 −/− n = 7–8).

D, E

Effect of SCAF1 loss of function on weight gain in mice after starvation. (D) Scheme of the food restriction experiment in mice. (E) Impact of food restriction in C57BL/6JOlaHsd mice with the functional version of SCAF1 113/113, with the spontaneous mutation in SCAF1 111/111 (natural C57BL/6JOlaHsd mice harbor a non‐functional version of SCAF1) and in C57BL/6JOlaHsd mice without SCAF1 (SCAF1 KO, −/−). Males 111/111 n = 3; males KO n = 6; males 113/113 n = 2; females 111/111 n = 5; females KO n = 8; females 113/113 n = 5.

Data information: (B, C) Two‐way ANOVA. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. (E) Data are represented as mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cox7a2l^brn1/brn1 cox7a2l^brn2/brn2
Observed In:	female organism female organism adipose tissue female organism fat cell male organism male organism adipose tissue male organism fat cell oocyte ovarian follicle stage IV
Stage:	Adult

Phenotype Detail

Acknowledgments

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