FIGURE

Fig. S6

ID

ZDB-FIG-200707-7

Publication

Nadar et al., 2020 - Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model

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Fig. S6

Cell death in zebrafish larvae brains due to PtPP treatment. A) After PtPP and cisplatin treatments, larvae brains were cleared and stained for apoptotic cells using the TUNEL assay. Confocal imaging of these stained larvae brains showed a basal level of apoptotic cells irrespective of PtPP and cisplatin treatments (indicated by white dashed line boxes pointing at TUNEL+ cells in the brain). Neurons are stained with HuC/D (green) and apoptotic cells are stained with TUNEL (magenta). Inserts show images at higher magnifications of the areas indicated with a white dashed line box. B) Quantification of the TUNEL+ cells in the zebrafish larvae brain after 2 days post treatment with PtPP and cisplatin. Cisplatin and PtPP treatments did not show any neurotoxic effect.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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