FIGURE

FIGURE 2

ID

ZDB-FIG-200702-17

Publication

Otten et al., 2020 - Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

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FIGURE 2

Microscopy of zebrafish embryos following TFAM knockdown. (A–H) Microscopic analysis following serial HE-staining of zebrafish embryos at 4 dpf, which were injected at 1 hpf with either 2 ng tfam splice-MO (B–E) or 2 ng Ctrl-MO, (A,C,E,G)n = 13 each condition. (B) The cerebellum was missing in the phenotype or a delayed development of this cerebellum in these fish. (D) The eyes were smaller and the eye layers were less developed. (F) A muscle phenotype was clearly visible in the dorsal fin, especially in the myotomic area, which was less compact in these somatic muscles. (H) The fish displayed a marked pericardial oedema (red arrow). They did not develop a normally looped heart as in Ctrl-MO (G), but the hearts were dilated in the phenotypes (H).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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