FIGURE

Figure 6

ID

ZDB-FIG-200530-32

Publication

Lee et al., 2020 - Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration

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Figure 6

Alk5 and PP2A inhibition rescues Tgfb3-mediated inhibition of MG proliferation in the injured retina.

(A) Experimental time line. (B) Edu click chemistry identifies proliferating MG in retinal sections from injured Wt and hsp70:tgfb3 transgenic fish treated with heat shock, +/- okadaic acid (OKA), PD169316 (PD), or SB431542 (SB) treatment. Scale bar is 50 microns. (C) Quantification of the effects of OKA, PD, and SB on Tgfb3-mediated suppression of MG proliferation that is shown in (B). Edu values are normalized to MG proliferation in Tgfb3 overexpressing transgenic fish. Error bars are SD. **p<0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT mi51Tg
Conditions:	chemical treatment by environment: okadaic acid, heat shock, surgical manipulation: retina chemical treatment by environment: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, heat shock, surgical manipulation: retina surgical manipulation: retina chemical treatment by environment: SB 431542, heat shock, surgical manipulation: retina
Observed In:	Muller cell cell population proliferation retina cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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