FIGURE

FIGURE 4

ID

ZDB-FIG-200423-58

Publication

Zhu et al., 2020 - Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development

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FIGURE 4

Heart defects was successfully rescued in Mdgcr8, but not in MZdgcr8. (A) The cardiac progenitor cells failed to migrate to the middle-line at prim-16 stage (32 hpf) in Mdgcr8 and MZdgcr8 (red arrows). (B) After miR430 rescue, cardiogenesis appeared normal including structure of atrium and ventricle. (C) MZdgcr8 failed to be rescued by mir430, exhibiting hydropericardium phenotype. (D,E) Heart-rate results indicated that the heart defects were completely rescued in Mdgcr8, but only partially in MZdgcr8, and MZdgcr8 heart rate gradually decreased at 4 days. **p < 0.01, ***p < 0.001, and ****p < 0.0001.

Expression Data

Gene:	myl7
Fish:	WT dgcr8^zf1064/+; ihb7Tg; zf1065Tg dgcr8^{zf1064/zf1064}; ihb7Tg; zf1065Tg
Anatomical Term:	cardiac muscle myoblast
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dgcr8^zf1064/+; ihb7Tg; zf1065Tg dgcr8^{zf1064/zf1064}; ihb7Tg; zf1065Tg
Observed In:	cardiac muscle myoblast heart heart contraction
Stage Range:	Prim-15 to Day 4

Phenotype Detail

Acknowledgments

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