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FIGURE 4

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ZDB-IMAGE-200423-59
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Figures for Zhu et al., 2020
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FIGURE 4

Heart defects was successfully rescued in Mdgcr8, but not in MZdgcr8. (A) The cardiac progenitor cells failed to migrate to the middle-line at prim-16 stage (32 hpf) in Mdgcr8 and MZdgcr8 (red arrows). (B) After miR430 rescue, cardiogenesis appeared normal including structure of atrium and ventricle. (C) MZdgcr8 failed to be rescued by mir430, exhibiting hydropericardium phenotype. (D,E) Heart-rate results indicated that the heart defects were completely rescued in Mdgcr8, but only partially in MZdgcr8, and MZdgcr8 heart rate gradually decreased at 4 days. **p < 0.01, ***p < 0.001, and ****p < 0.0001.

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