FIGURE

Figure 4.

ID

ZDB-FIG-200421-66

Publication

Scaletti et al., 2020 - MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

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Figure 4.

Activity with N6-methyl-dATP is unique to MTH1 within human NUDIX subfamily. Activities of human NUDIX enzyme (MTH1, NUDT15, NUDT17, and NUDT18) were assayed with data points in quadruplicate with 50 μm dATP or N6-methyl-dATP at 20 and 200 nm enzyme in MTH1 reaction buffer (pH 8.0). 0.2 units/ml of PPase was used to convert formed PP_i to P_i that was detected using malachite green reagent and measurement of absorbance at 630 nm. Graph shows mean ± S.D. from one experiment performed in triplicate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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