FIGURE

Fig. 1

ID

ZDB-FIG-200406-189

Publication

Pei et al., 2020 - A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation

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Fig. 1

Hair cell regeneration analysis for mutations in each gene of the SMN complex.

Hair cell regeneration is impaired by homozygous mutations of gemin3^hg105a, smn1^hg104b, and gemin5^hg107c, but not in gemin2^hg108d, gemin4^hg109e, gemin6^hg110f, gemin7^hg111g, gemin8^hg112h, or strap^hg113i. Red line separates the mutations impacting regeneration from those that have no effect on regeneration. wt wild-type, het heterozygotes, hom homozygotes. Error bars in the graphs represent mean ± s.e.m. The difference between wild-type and homozygote is labeled. ns, P > 0.05; ***P < 0.001; ****P < 0.0001. Approximately 40 embryos were used for each of the regeneration analyses and then genotyped to study the genotype–phenotype correlation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ddx20^hg105/hg105 gemin2^hg108/hg108 gemin4^hg109/hg109 gemin5^hg107/hg107 gemin6^hg110/hg110 gemin7^hg111/hg111 gemin8^hg112/hg112 smn1^hg104/hg104 strap^hg113/hg113
Condition:	chemical ablation: neuromast hair cell, chemical treatment by environment: copper(II) sulfate
Observed In:	neuromast hair cell neuromast hair cell regeneration neuromast regeneration posterior lateral line neuromast
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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