FIGURE

Figure 5

ID

ZDB-FIG-200326-13

Publication

L et al., 2020 - ZnO Nanoparticles Induced Caspase-Dependent Apoptosis in Gingival Squamous Cell Carcinoma through Mitochondrial Dysfunction and p70S6K Signaling Pathway

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Figure 5

Effects of ZnO-NPs on caspase cascade in human GSCC cells. Ca9-22 cells were treated with the indicated concentrations of ZnO-NPs for 24 h. Then, cells were harvested and lysed for the detection of initiator caspase (caspase -8 and -9) (a), caspase-3, and poly-(ADP-ribose) polymerase (PARP) (b) by Western blot analysis. (c) The quantitative densitometry of cleaved form of the indicated caspases and PARP was performed with Image-Pro Plus. (d) Percentage cell viability assessed by MTT assay in GSCC cells, which were treated with ZnO-NPs in the presence or absence of Z-VAD-FAK. Data represent the mean ± SEM of three independent experiments. * p < 0.05 compared with the control group, # p < 0.05 compared to ZnO-NP-treated cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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