FIGURE

Figure 1

ID

ZDB-FIG-200302-36

Publication

Marques et al., 2020 - Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish

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Figure 1

LDIR upregulate the expression of several pro-angiogenic factors in Fli1:EGFP zebrafish in a VEGFR-dependent manner. Fli1:EGFP zebrafish larvae were exposed or not to 0.5 Gy at 3, 4 and 5 dpf and pre-treated or not with PTK/ZK, 30 minutes before each irradiation. The mRNA expression of flt1, kdr, angpt2a, tgfb2, fgf2, and cyr61 from whole cell suspension and endothelial sorter cells was quantified by qRT-PCR and normalized to elongation factor 1. (A) Data represent the relative mRNA levels of whole cell suspension and endothelial sorted cells from larvae exposed LDIR relative to the non-irradiated one (dashed line), in triplicate measurements. **P < 0.01; ***P < 0.001; ns, non-significant. (B) Data represent the fold change in mRNA expression of whole cell suspension and endothelial sorted cells of irradiated larvae exposed to PTK-ZK relative to non-irradiated and untreated ones, in triplicate measurements. Data are representative of six independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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