FIGURE

Figure 6.

ID

ZDB-FIG-200210-44

Publication

Nagashima et al., 2019 - Midkine-a is required for cell cycle progression of Müller glia glia during neuronal regeneration in the vertebrate retina

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Figure 6.

Müller glia in the mdka^mi5001 mutant dedifferentiate following photoreceptor death. A, Immunocytochemistry for regeneration-associated genes, Rx1 and Sox2, following photolytic lesion in WT and mdka^mi5001 retinas. Lesion induces Rx1 and Sox2 expression in Müller glia both in WT and mdka^mi5001 retinas at 2 dpl. B, The mdka^mi5001 retinas carrying the Müller glial reporter, Tg(gfap:eGFP)^mi2002. Photoreceptor injury induces interkinetic nuclear migration of Müller glial nuclei in the mdka^mi5001 mutant. Arrows indicate cell bodies of Müller glia. The nuclei were stained with Hoechst (gray). OLM, Outer limiting membrane; inl, inner nuclear layer; onl, outer nuclear layer. Scale bars, 30 μm.

Expression Data

Antibodies:	Ab1-rx1 Ab11-sox2
Fish:	AB mdka^{mi5001/mi5001} (AB)
Condition:	light damage: eye photoreceptor cell
Anatomical Term:	regenerating tissue Muller cell
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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