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Figure 6.

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ZDB-IMAGE-200210-46
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Figures for Nagashima et al., 2019
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Figure 6.

Müller glia in the mdkami5001 mutant dedifferentiate following photoreceptor death. A, Immunocytochemistry for regeneration-associated genes, Rx1 and Sox2, following photolytic lesion in WT and mdkami5001 retinas. Lesion induces Rx1 and Sox2 expression in Müller glia both in WT and mdkami5001 retinas at 2 dpl. B, The mdkami5001 retinas carrying the Müller glial reporter, Tg(gfap:eGFP)mi2002. Photoreceptor injury induces interkinetic nuclear migration of Müller glial nuclei in the mdkami5001 mutant. Arrows indicate cell bodies of Müller glia. The nuclei were stained with Hoechst (gray). OLM, Outer limiting membrane; inl, inner nuclear layer; onl, outer nuclear layer. Scale bars, 30 μm.

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