FIGURE

Figure 7—figure supplement 1.

ID
ZDB-FIG-200208-32
Publication
Honkoop et al., 2019 - Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart
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Figure 7—figure supplement 1.

Activation of ErbB2 signaling in murine MI model induces glycolytic gene expression while repressing mitochondrial genes.

(a) Cartoon showing experimental procedure. Myocardial infarction (MI) was induced by left anterior descending coronary artery ligation at the same day when Dox was removed to induce cardiomyocyte specific caErbB2 overexpression (OE). Whole hearts where isolated for mRNA extraction 14 days after the MI and caErbB2 induction. (b) qPCR results with relative mRNA fold changes comparing wild type (WT, blue bars) with caErbB2 OE (OE, orange bars). Note the significant upregulation of glycolytic genes (Pfkp, Pdk3 and Pgk1) and significant downregulation of genes transcribed from the mitochondrial DNA (Mt-Nd1, Mt-Co2, Mt-Co1 and Mt-Co3). Bars represent mean values and error bars represent standard deviation. *p<0,05; **p<0,01; ***p<0001.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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