FIGURE

Figure 1—figure supplement 1.

ID

ZDB-FIG-200208-19

Publication

Honkoop et al., 2019 - Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Other Figures

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Figure 1—figure supplement 1.

<italic>TgBAC(nppa:mCitrine)</italic> expression recapitulates endogenous <italic>nppa</italic> gene expression.

(a) Design of the bacterial artificial chromosome (BAC) used for generation of the transgenic line TgBAC(nppa:mCitrine). (b) Transgenic mCitrine expression in the heart in relation to RFP expression in the whole myocardium of Tg(myl7:GFF, UAS:RFP, nppa:mCitrine) in embryos at 2 days post-fertilization (dpf). (c) Whole mount in situ hybridization for endogenous nppa expression in embryos at two dpf. Note the specific expression in ventricle and atrium and absence of expression in atrioventricular canal of the nppa:mCitrine transgene expression (in panel b) as well as for the endogenous nppa expression (in panel c). (d, e) Endogenous nppa expression (d) and nppa:mCitrine expression (e) in the adult heart at 7 days post-injury (dpi). Note expression of nppa:mCitrine in the cortical borderzone (arrowheads). (f) Fluorescent in situ hybridization for nppa performed on gata4:EGFP hearts 7dpi. Note the overlap of nppa and gata4:EGFP in trabecular borderzone cardiomyocytes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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