FIGURE

Figure 9

ID

ZDB-FIG-191230-1696

Publication

Dóró et al., 2019 - Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms

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Figure 9

Onset of anaemia during <italic>T. carassii</italic> infection.

Zebrafish larvae (5 dpf) were infected with 200 T. carassii or injected with PVP as non-infected control. Images are selected frames depicting the caudal artery, extracted from high-speed videos where trypanosomes (white open-arrow heads) and red blood cells (RBC, black open-arrow heads) were identified and tracked. (A) Artery of a control, non-infected, fish. Only RBC are present. (B) Artery of an infected fish, 1 dpi, showing a high ratio of RBC:trypanosomes. This frame corresponds to seconds 04:20-04:23 in Video 3, where the same trypanosomes were tracked. (C) Artery of an infected fish, 6 dpi, showing a reduced ratio of RBC:trypanosomes, indicating the onset of anaemia. (D) Artery of an infected fish suffering from severe anaemia, 8dpi, where only trypanosomes are present. The frame is extracted from the corresponding Video 9. Scale bars indicate 25 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	protozoan treatment: Trypanosoma carassii
Observed In:	blood vasculature nucleate erythrocyte
Stage:	Day 6

Phenotype Detail

Acknowledgments

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