FIGURE

Fig. 3

ID

ZDB-FIG-191028-6

Publication

Brun et al., 2019 - Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish

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Fig. 3

Effects of PSNPs on glucose metabolism in larval zebrafish. a Dose-dependent response showing glucose concentrations in zebrafish embryos wild-type (AB/TL and gr+/+), glucocorticoid receptor mutant (gr?/?), and AB/TL supplemented with the glucocorticoid receptor antagonist mifepristone (1?�M; n?=?4?5, pool of ten zebrafish per sample). b Representative image of insulin staining of the pancreas in control and 20?mg?L^?1 PSNP-exposed embryos (n?=?7, biologically independent replicates). c Dose-response showing pck1 promoter dynamics in Tg(pck1:Luc2)zebrafish larvae at 120?hpf after exposure to 0.2?mg?L^?1 (low), 2?mg?L^?1 (mid), and 20?mg?L^?1(high) PSNPs from 72 to 120?hpf (n?=?5, pool of three zebrafish per sample). Values are presented as mean?�?SD. Asterisks indicate significant differences to controls (*p?<?0.05, **p?<?0.01, and ***p?<?0.001)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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