FIGURE

Fig. 5

ID

ZDB-FIG-190913-71

Publication

Toms et al., 2019 - Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy

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Fig. 5

Altered mitochondrial morphology in the obe^td15 cone photoreceptors. Ultrastructural examination of the cone photoreceptors in 6 months post fertilization (mpf) wild-type (WT) (a–d) and obe^td15 fish (e–h). A red-green cone inner segment is highlighted on (a) (red dotted circle). Higher magnification images showed an altered morphology of the mitochondria in the obe^td15 red-green cone inner segments (f–h). Electron-lucent mitochondria (black asterisks) were enlarged and electron-dense mitochondria (white asterisks) were rounder and less closely packed. The electron-dense mitochondria had juxtaposition of the cristae membranes (white arrow). IS, inner segments; OS, outer segments. Scale bars = 20 µm (a,e), 5 µm (b,f) and 1 µm (c,d,g,h).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnj13^td15/td15
Observed In:	retinal cone cell mitochondrion
Stage:	Adult

Phenotype Detail

Acknowledgments

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