FIGURE

Figure 5

ID

ZDB-FIG-190723-1330

Publication

Xie et al., 2019 - Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

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Figure 5

Aurones 5a and 5b inhibited myc-induce T-ALL in a zebrafish model. (A,D) Treatment of GFP-labeled thymic lymphoma cells with DMSO alone at day 0 and day 5, respectively. (B,E) Treatment of GFP-labeled thymic lymphoma cells with aurone 5a in DMSO at day 0 and day 5, respectively. (C,F) Treatment of GFP-labeled thymic lymphoma cells with aurone 5b at day 0 and day 5, respectively. (G) Percent change in fluorescence (i.e., number of GFP-labeled thymic lymphoma cells) as a function of time from administration of DMSO alone to the administration of aurone 5b in each zebrafish (n = 8).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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