FIGURE

Figure 2

ID

ZDB-FIG-190723-1326

Publication

Xie et al., 2019 - Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

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Figure 2

(A) Dose responses of aurones 5a and 5b in PC-3 cell proliferation inhibition assay. (B) Effect of aurone 5a on PC-3 tumor xenografts in nude mice (n = 5) at 10 mg/kg/day. (C) Effect on aurone 5a on body weights of the treated mice: *P < 0.05, t-test. (D) H&E analysis of tumor sections. (E). Apoptosis analysis by TUNEL assay. (F). IHC analysis of angiogenesis marker, VEGF-A.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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