FIGURE

FIG 6

ID

ZDB-FIG-190723-124

Publication

Archambault et al., 2019 - Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis

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FIG 6

Both C. albicans and C. parapsilosis elicit macrophage recruitment. Transgenic mpeg1:GAL4/UAS:nfsB-mCherry zebrafish (red macrophages) were infected and imaged at 24 hpi. (A to C) Representative images of zebrafish swimbladders injected with the vehicle (A), C. parapsilosis (B), and C. albicans (C). Maximum projections of 16 slices (A) and 13 slices (B and C), with (left) and without (right) a single DIC z-slice, are shown. (D) Numbers of macrophages per fish in the swimbladder lumen. Data were pooled from 7 independent experiments. (E) Numbers of macrophages per fish involved in interactions with C. parapsilosis or C. albicans. (F) Percentages of interacting macrophages engaged in phagocytosis. (G) Numbers of macrophages per fish interacting with fungi. Numbers of macrophages scored for the vehicle, C. parapsilosis, and C. albicans were 137, 135, and 367, respectively. Statistics are described in Materials and Methods (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant [P > 0.05]). Bars, 150 μm (A to C).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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