FIGURE

Fig. 2

ID

ZDB-FIG-190716-24

Publication

Rocker et al., 2019 - Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio Rerio) following nitroreductase-mediated β-cell ablation

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Fig. 2

Acute hyperglycemia affects ensheathment by the perineurium. A: in control ins:NTR;Tg(nkx2.2a:megfp) fish 7 days postfertilization (dpf), the perineurium is present in regular intervals (asterisks) along the spinal cord. NTR, nitroreductase; megfp, monomeric enhanced green fluorescent protein. B: following the schedule of treatment described in Fig. 1A, nkx2.2a⁺ perineurial glia in ins:NTR;Tg(nkx2.2a:megfp) fish are stalled at the motor exit point along the spinal cord (white arrows) and are occasionally observed in ectopic locations (arrowhead). MTZ, metronidazole. Scale bar = 50 μm. C: percentage of nerves in which perineurial glia were present was higher in control than MTZ-treated fish. ****P < 0.0001. D: fewer nerves were properly ensheathed by the perineurium in MTZ-treated than control fish. ****P < 0.0001. E: perineurial segments along the peripheral nerve were shorter in MTZ-treated than control fish. ****P < 0.0001.

Expression Data

Gene:	EGFP
Fish:	jh4Tg; w61Tg
Condition:	chemical treatment by environment: metronidazole
Anatomical Terms:	dorsal root ganglion sensory neuron sensory neuron
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jh4Tg; w61Tg
Condition:	chemical ablation: pancreatic B cell, chemical treatment by environment: metronidazole
Observed In:	sensory neuron thigmotaxis
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Regul. Integr. Comp. Physiol.