FIGURE

Fig. 2

ID

ZDB-FIG-190708-4

Publication

Xu et al., 2017 - JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide

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Fig. 2

JAM-A indicated B-lymphoma cell stemness. (A) As assessed by Whole-mount in Situ Hybridization and real-time quantitative RT-PCR, c-myb and runx1 were overexpressed after 26 h microinjecting jam-1 mRNA (jam-1) in Zebrafish embryos. WT, wild type. (B,C) B-lymphoma cell line DB and SU-DHL-4 were transfected with control vector (Vector) and JAM-A vector (JAM-A). Ectopic expression of JAM-A was associated with increased colony formation (B) and stem-cell marker CD133 and CD34 expression (C). (D) DLBCL patients with high JAM-A expression displayed increased CD133 positivity. (E) Patients in high JAM-A expression group were enriched for a stem cell gene signature, as revealed by RNA sequencing. Data in (A), (B) and (C) are representative of three independent experiments.

Expression Data

Genes:	myb runx1
Fish:	WT
Anatomical Term:	hematopoietic multipotent progenitor cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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