FIGURE

Fig. 8

ID

ZDB-FIG-190626-55

Publication

Chopra et al., 2019 - Zebrafish duox mutations provide a model for human congenital hypothyroidism

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Fig. 8

The goitrogen methimazole (MMI) phenocopies duox mutations. A and B show a 5× magnification of the distribution of melanophores on the flank region among MMI-treated and untreated WT fish. Treated animals have at least two distinct populations of melanophores, based on size (A,B). Pigment change pertaining to melanophore numbers is significant following MMI treatment (C). (Bonferroni's multiple comparisons **P<0.01). MMI leads to loss of bound T₄in WT larvae (D,E) and induces external goitre (arrowhead; F). ISH for thyroglobulin reveals widespread follicular tissue, not limited to the mid-ventral region (H), similar to duox mutants (I). Scale bars: 1 mm.

Expression Data

Gene:	tg
Antibody:	Ab2-T4
Fish:	AB duox^{sa9892/sa9892}
Condition:	chemical treatment by environment: methimazole
Anatomical Term:	thyroid follicle
Stage Range:	Day 5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB duox^{sa9892/sa9892}
Condition:	chemical treatment by environment: methimazole
Observed In:	melanocyte melanophore stripe thyroid follicle thyroid follicle thyroxine thyroid gland development
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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