FIGURE

Fig. 7

ID

ZDB-FIG-190626-54

Publication

Chopra et al., 2019 - Zebrafish duox mutations provide a model for human congenital hypothyroidism

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Fig. 7

T₄ treatment alleviates phenotypic anomalies in duox mutants. T₄-treated mutants show an improvement in fin health, compared to untreated mutants (A,B). Pigment changes are evident among T₄-treated mutants. C–F show a 5× magnification of the distribution of melanophores on the flank region of sa9892^+/− and sa989^−/− siblings, with a significant reduction in melanophore number (G). Asterisks denote statistically significant differences (Bonferroni's multiple comparisons test, ****P<0.0001). Goitres resolve following T₄ administration, but small ectopic thyroids are still evident (black arrowheads) (I,J). Scale bars: 1 mm.

Expression Data

Gene:	tg
Fish:	duox^{sa9892/sa9892}
Condition:	chemical treatment by environment: thyroxine
Anatomical Term:	thyroid follicle
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	duox^{sa9892/sa9892} duox^sa9892/+
Condition:	chemical treatment by environment: thyroxine
Observed In:	anal fin caudal fin dorsal fin female organism male organism melanocyte melanophore stripe thyroid follicle
Stage:	Adult

Phenotype Detail

Acknowledgments

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