Gene

tg

ID
ZDB-GENE-030519-1
Name
thyroglobulin
Symbol
tg Nomenclature History
Previous Names
  • cb717 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable hormone activity. Predicted to be involved in thyroid hormone generation. Predicted to act upstream of or within hormone biosynthetic process. Located in extracellular region. Is expressed in pharyngeal arch; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
36 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thyroid dyshormonogenesis 3 Alliance Thyroid dyshormonogenesis 3 274700
{Autoimmune thyroid disease, susceptibility to, 3} 608175
Associated With tg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Domain IPR002018 Carboxylesterase, type B
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Carboxylesterase, type B Thyroglobulin type-1 Thyroglobulin type-1 superfamily Tyrosine-protein kinase ephrin type A/B receptor-like
UniProtKB:F1QFR0 2741
UniProtKB:A0A193GP06 2733
UniProtKB:Q2VA53 336
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tg polyclonal Rabbit
  • IHC
  • WB
Dako North America, Inc.
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations