FIGURE

Fig. 1

ID

ZDB-FIG-190530-29

Publication

DuVal et al., 2018 - Photoreceptor Progenitors Depend Upon Coordination of gdf6a, thrβ, and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes

Other Figures

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Fig. 1

gdf6a loss in tbx2b heterozygous fby carriers reduces UV cone abundance. (A) Relative abundances of UV, blue, and red cones in compound gdf6a^+/s327; tbx2b^+/fby in-crosses show near-complete loss of UV cones in tbx2b^fby/fby mutants and partial loss of UV cones in tbx2b^+/fby mutants with gdf6a^s327/s327 background (labeled gdf6a^−/− or “−/−”). Values with matching letters are not significantly different (Kruskal-Wallis test with Mann-Whitney pairwise comparisons, gray asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001 relative to wild type (WT)/WT controls). Gdf6a^s327/s327 mutants have reduced blue cones and a novel reduced red cone abundance phenotype, both of which appear either unaffected or slightly enhanced by tbx2b loss. Wild-type values shown are sibling controls. (B) Representative retinal images depicting UV (magenta), blue (cyan), and red cones (green) in wild type, gdf6a^s327/s327, tbx2b^fby/fby, and compound gdf6a^s327/s327; tbx2b^+/fby mutants.

Expression Data

Antibodies:	Ab1-10C9.1 Ab3-rho
Fish:	WT gdf6a^s327/s327 tbx2b^c144/c144 gdf6a^s327/s327; tbx2b^c144/+
Anatomical Terms:	red sensitive photoreceptor cell UV sensitive photoreceptor cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gdf6a^s327/s327 tbx2b^c144/c144 gdf6a^s327/+; tbx2b^c144/c144 gdf6a^s327/s327; tbx2b^c144/+ gdf6a^s327/s327; tbx2b^c144/c144
Observed In:	blue sensitive photoreceptor cell red sensitive photoreceptor cell UV sensitive photoreceptor cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.