Image
|
Figure Caption
Fig. 1
gdf6a loss in tbx2b heterozygous fby carriers reduces UV cone abundance. (A) Relative abundances of UV, blue, and red cones in compound gdf6a+/s327; tbx2b+/fby in-crosses show near-complete loss of UV cones in tbx2bfby/fby mutants and partial loss of UV cones in tbx2b+/fby mutants with gdf6as327/s327 background (labeled gdf6a−/− or “−/−”). Values with matching letters are not significantly different (Kruskal-Wallis test with Mann-Whitney pairwise comparisons, gray asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001 relative to wild type (WT)/WT controls). Gdf6as327/s327 mutants have reduced blue cones and a novel reduced red cone abundance phenotype, both of which appear either unaffected or slightly enhanced by tbx2b loss. Wild-type values shown are sibling controls. (B) Representative retinal images depicting UV (magenta), blue (cyan), and red cones (green) in wild type, gdf6as327/s327, tbx2bfby/fby, and compound gdf6as327/s327; tbx2b+/fby mutants.
Figure Data
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Invest. Ophthalmol. Vis. Sci.