ZFIN ID: ZDB-FISH-150901-23081
Fish name: gdf6as327/s327
Genotype: gdf6as327/s327
Targeting Reagent: none
HUMAN DISEASE MODELED by gdf6as327/s327
Human Disease Conditions Citations
microphthalmia standard conditions French et al., 2013
GENE EXPRESSION
Gene expression in gdf6as327/s327
RNA expression
Expressed Gene Structure Conditions Figures
aldh1a2 standard conditions Fig. S8 with image from Hocking et al., 2018
atoh7 standard conditions Fig. S1 from French et al., 2013
bmp2b standard conditions Fig. 4 with image from Gosse et al., 2009
bmp4 standard conditions Fig. 4 with image from Gosse et al., 2009
cad standard conditions Fig. 5 from French et al., 2013
cyp1b1 standard conditions Fig. S8 with image from Hocking et al., 2018
efnb2a standard conditions Fig. 4 with image from Gosse et al., 2009
epha4b standard conditions Fig. 4 with image from Gosse et al., 2009
foxi1 standard conditions Fig. 7 from French et al., 2013
foxi2 standard conditions Fig. 7 from French et al., 2013
foxn4 standard conditions Fig. S1 from French et al., 2013
gdf6a standard conditions Fig. 2 with image from Gosse et al., 2009
hmx1 standard conditions Fig. S1 from French et al., 2013
kdrl standard conditions Fig. 3 from Krispin et al., 2017
mcm3 standard conditions Fig. 5 from French et al., 2013
myca standard conditions Fig. 2Fig. 5 from French et al., 2013
mych standard conditions Fig. 2Fig. 5 from French et al., 2013
mycn standard conditions Fig. 5 from French et al., 2013
opn1sw1 standard conditions Fig. 4 with image from Duval et al., 2014
opn1sw2 standard conditions Fig. 4 with image from Duval et al., 2014
pcna standard conditions Fig. 5 from French et al., 2013
rx1 standard conditions Fig. 5 from French et al., 2013
smad1 standard conditions Fig. 5 from Pant et al., 2013
smad5 standard conditions Fig. 5 from Pant et al., 2013
smad7 standard conditions Fig. 5 from Pant et al., 2013
smad9 standard conditions Fig. 5 from Pant et al., 2013
tbx2b standard conditions Fig. 6 with image from Hocking et al., 2018
Fig. 3 with image from Duval et al., 2014
Fig. S1 from French et al., 2013
Fig. 4 with image from Gosse et al., 2009
tbx4 standard conditions Fig. S1 from French et al., 2013
tbx5a standard conditions Fig. 5 from Hocking et al., 2018
Fig. 4 with image from Gosse et al., 2009
chemical treatment by environment: Cyclopamine Fig. 5 from Hocking et al., 2018
uhrf1 standard conditions Fig. 5 from French et al., 2013
vax2 standard conditions Fig. 4 with image from Gosse et al., 2009
Protein expression
Antibody Antigen Genes Structure Conditions Figures
Ab1-casp3 standard conditions Fig. 3 from French et al., 2013
Fig. 1Fig. 2Fig. 3Fig. 4 from Pant et al., 2013
Ab1-casp3 chemical treatment: pharmaceutical Fig. 3 from French et al., 2013
Fig. 4 from Pant et al., 2013
Ab1-eng standard conditions Fig. 7 with image from Nguyen-Chi et al., 2012
Ab1-chat standard conditions Fig. 3 with image from DuVal et al., 2014
Ab3-syp standard conditions Fig. 3 with imageFig. 5 with image from DuVal et al., 2014
Ab22-h3 standard conditions Fig. 2Fig. 6 from French et al., 2013
zpr-1 standard conditions Fig. 3 from Asai-Coakwell et al., 2013
Reporter gene expression No data available
PHENOTYPE
Phenotype in gdf6as327/s327
Phenotype Conditions Figures
cartilage morphogenesis disrupted, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratobranchial 1 cartilage mislocalised anteriorly, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratobranchial 1 cartilage orientation ceratobranchial 1 cartilage, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratobranchial 2 cartilage mislocalised anteriorly, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratobranchial 2 cartilage orientation ceratobranchial 2 cartilage, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratohyal cartilage mislocalised medially, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratohyal cartilage obtuse angle to ceratohyal cartilage, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ceratohyal cartilage overlap with ceratohyal cartilage, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
ciliary marginal zone cell population proliferation decreased process quality, abnormal standard conditions Fig. 6 from French et al., 2013
dorsal aorta cell-cell junction decreased length, abnormal standard conditions Fig. 5 from Krispin et al., 2017
dorsal aorta cell-cell junction hypoplastic, abnormal standard conditions Fig. 5 from Krispin et al., 2017
dorsal aorta cell-cell junction structure, abnormal standard conditions Fig. 5 from Krispin et al., 2017
eye tbx2b expression decreased amount, abnormal standard conditions Fig. 6 with image from Hocking et al., 2018
eye decreased size, abnormal chemical treatment: pharmaceutical Fig. 3 from French et al., 2013
eye decreased size, abnormal standard conditions Fig. 1 from Krispin et al., 2017
Fig. 1 with image from DuVal et al., 2014
Fig. 1 with imageFig. 2 with image from Duval et al., 2014
Fig. 3 from Asai-Coakwell et al., 2013
Fig. 1Fig. 3Fig. 8 from French et al., 2013
Fig. 1 with image from Gosse et al., 2009
eye morphology, abnormal standard conditions Fig. 4 with image from Hocking et al., 2018
eye apoptotic process increased process quality, abnormal standard conditions Fig. 3 from French et al., 2013
Fig. 1 from Pant et al., 2013
eye cell population proliferation decreased process quality, abnormal standard conditions Fig. 6 from French et al., 2013
eye dorsal region aldh1a2 expression absent, abnormal standard conditions Fig. S8 with image from Hocking et al., 2018
eye intrinsic apoptotic signaling pathway increased process quality, abnormal control Fig. 3 from Pant et al., 2013
hypobranchial cartilage decreased width, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
hypobranchial cartilage notched, abnormal standard conditions Fig. 2 with image from Reed et al., 2010
lens shape, abnormal standard conditions Fig. 1 with image from Duval et al., 2014
melanocyte spatial pattern, abnormal standard conditions Fig. 1 from Krispin et al., 2017
motor neuron neuromuscular junction increased volume, abnormal standard conditions Fig. 3 with imageFig. 5 with image from DuVal et al., 2014
motor neuron neuromuscular junction physical object quality, abnormal standard conditions Fig. 5 with image from DuVal et al., 2014
Muller cell disorganized, abnormal standard conditions Fig. 3 from Asai-Coakwell et al., 2013
muscle pioneer increased amount, abnormal standard conditions Fig. 7 with image from Nguyen-Chi et al., 2012
optic cup dorsal region tbx5a expression absent, abnormal chemical treatment by environment: Cyclopamine Fig. 5 from Hocking et al., 2018
optic cup dorsal region tbx5a expression absent, abnormal control Fig. 5 from Hocking et al., 2018
optic fissure mislocalised, abnormal standard conditions Fig. 2 with imageFig. 4 with image from Gosse et al., 2009
optic fissure morphology, abnormal standard conditions Fig. 2 with imageFig. 4 with image from Gosse et al., 2009
optic tectum has fewer parts of type retinal ganglion cell neuron projection, abnormal standard conditions Fig. 1 with image from Gosse et al., 2009
optomotor response decreased occurrence, abnormal control Fig. 8 from Hagerman et al., 2016
optomotor response decreased process quality, abnormal control Fig. 8 from Hagerman et al., 2016
optomotor response disrupted, abnormal standard conditions Fig. S4 from Asai-Coakwell et al., 2013
pupil morphology, abnormal standard conditions Fig. 3 from Asai-Coakwell et al., 2013
retina apoptotic, abnormal standard conditions Fig. 4 from Asai-Coakwell et al., 2013
retina has fewer parts of type blue sensitive photoreceptor cell, abnormal standard conditions Fig. 4 with image from Duval et al., 2014
retina dorsal/ventral pattern formation process quality, abnormal standard conditions Fig. 4 with image from Gosse et al., 2009
retina layer formation disrupted, abnormal standard conditions Fig. 3 from Asai-Coakwell et al., 2013
retinal cone cell morphology, abnormal standard conditions Fig. 3 from Asai-Coakwell et al., 2013
retinal ganglion cell axon guidance process quality, abnormal standard conditions Fig. 1 with image from Gosse et al., 2009
retinal neural layer absent, abnormal standard conditions Fig. 1 with image from Duval et al., 2014
retinal photoreceptor layer lacks parts or has fewer parts of type retinal cone cell, abnormal standard conditions Fig. 3 from Asai-Coakwell et al., 2013
spinal cord lacks parts or has fewer parts of type motor neuron, abnormal standard conditions Fig. 3 with image from DuVal et al., 2014
superior ocular sulcus closure incomplete, abnormal standard conditions Fig. 4 with image from Hocking et al., 2018
superior ocular sulcus morphology, abnormal standard conditions Fig. 4 with image from Hocking et al., 2018
trunk vasculature broken, abnormal standard conditions Fig. 1 from Krispin et al., 2017
trunk vasculature hemorrhagic, abnormal standard conditions Fig. 1 from Krispin et al., 2017
trunk vasculature kdrl expression increased amount, abnormal standard conditions Fig. 3 from Krispin et al., 2017
whole organism kdrl expression increased amount, abnormal standard conditions Fig. 3 from Krispin et al., 2017
whole organism lethal (sensu genetics), abnormal standard conditions text only from Gosse et al., 2009

CITATIONS  (14)