FIGURE

Fig. 1

ID

ZDB-FIG-190201-2

Publication

Gamble et al., 2018 - Quantification of glioblastoma progression in zebrafish xenografts: Adhesion to laminin alpha 5 promotes glioblastoma microtumor formation and inhibits cell invasion

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Zebrafish Brain Xenograft. A) Orthogonal views for Z-section of zebrafish brain with U251MG cells (red) and blood vessels (green) at 1 (left) and 4 (right) day post injection displaying microtumor formation (yellow arrow) occurring deep in brain surrounded with blood vessels. B) Representative panels of calculating U251MG cells associations with blood vessels (BV); 100  μm scale bar. C) Maximum projection image frame of 3D time-lapse image of zebrafish brain with blood vessels (green) and transplanted U251MG cells (red) with areas of interest indicated. Blue box: BV attachment. Yellow box: GBM cell invasion. D) Representative time-lapse images of U251MG cell attaching to blood vessels (blue circle) and constricting with pseudopodium (blue arrows). E) Representative time-lapse images of U251MG cell invading zebrafish brain (yellow arrows) and non-invasive U251MG cells (yellow circle). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biochem. Biophys. Res. Commun.